Stem cells based from the adipose tissue play an important role for treating the atopic dermatitis which is popularly known as eczema. Atopic dermatitis, also called eczema is a relapsing or chronic inflammatory disease that cause dry, crusty and itchy red skin. The condition is related to elevated immunoglobin levels and sensitivity to number of allergens. It is caused because of dysfunctional regulation of the immune system of the skin because of the genetic and environmental factors.
How is it treated now?
The recent treatments usually emphasize on suppressing the immune system with the help of drugs but it can impact you on a long term. Patients are always prescribed with topical steroid creams but they may have dangerous effects. But now, Houston Stem Cell Treatment is also used to cure eczema.
What did the experiment involve?
The trial relieved the atomic dermatitis by making the used of the exosomes derived from the mesenchymal stem cells. In the experiment, mice were monitored with a number of exosomes either intravenously or subcutaneously for thrice a week in a month.
What was the outcome?
The research concluded that the ASC exosomes brought down the pathological symptoms of the atopic dermatitis like immunoglobin levels and the number of eosinophils in the blood with no impact on the overall white blood cell count. The eosinophils are referred to as disease fighting white cells. The stems also bring down the infiltration of mast cells which secret the histamine and other kind of substance during allergic or inflammatory responses that can cause dermatitis. Eventually, these stem cells eliminate tumor necrosis factor alpha which are cell signaling proteins or cytokins that can lead to systemic inflammation.
How did it cure eczema?
There are many studies focusing on effect of stem cells on eczema. The previous studies claimed that MSCs being derived from the cord blood could easily suppress the allergic progress in eczema or atopic dermatitis. They can interact with cell types of both innate and adaptive immune systems that lead to differentiation and activation of immune cells like B cells, T cells, natural killer cells, and dendritic cells. But there are more issues to look after like enhancing their poor engraftment efficiency, useless immune response, shorter half life and potential tumor formation. The results were quite positive by putting in umbilical cord mesenchymal stem cells subcutaneously. 55 percent patients noticed a 50 percent elimination on the Eczema Area and Severity Index or EASI and 50 percent elimination in SCORAD or Severity Scoring for Atopic Dermatitis. For patients with higher doses, they noticed a 50 percent reduction in itchiness.